Cutaneous marginal zone lymphoma of the nose arising after rhinoplasty with filler injection

Chronic inflammation induced by infection, autoimmune disorders, and immune reaction against foreign bodies are recognized as causative factors for the development of lymphoma. Here, a case B cell lymphoma arising after augmentation rhinoplasty with filler injection is reported. A 48-year-old Japanese woman underwent at cosmetic clinic 10 years ago. She, presently, came complaints nodule nasal root. Histologic examination biopsy specimen revealed diffuse infiltration centrocyte-like cells plasmacytic differentiation in subcutis procerus muscle. Immunohistochemistry showed that tumor were CD3?, CD5?, CD10?, CD20+, CD79+, bcl-2+, bcl-10+, IgG+, IgA?, IgM?. In situ hybridization Epstein-Barr virus small RNAs was negative. The final diagnosis extranodal marginal zone This body-induced carcinogenesis. Various aspects chronic propel discussed their morphology, immunophenotype, viral association.